The Clinician Alcohol Abuse Scale and Clinician Drug Use Scale are short, reliable, and valid measures that are suitable for use by clinicians. Comorbid substance abuse occurs in up to 50% of people with schizophrenia. However, there is evidence that the use of clozapine reduces suicidality and persistent suicidal ideation in patients with schizophrenia. Evidence for this comes from an innovative randomized controlled study in which increased suicidality was the primary outcome (3-fold overall reduction in risk of suicidal behaviors).
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