Binswangers disease

Otto Binswanger was born in Münsterlingen, Switzerland, on October 14, 1852. Otto Binswanger studied medicine in Heidelberg, Strasbourg, and Zurich. At the age of 30, Dr Binswanger was appointed professor of psychiatry and director of the mental asylum in Jena, a position he held for 37 years between 1882 and 1919.
In 1894, Binswanger first described a form of dementia called encephalitis subcorticalis chronica progressiva, separate from neurosyphilis and other forms of dementia in the elderly. He characterized the disease as being associated with lesions of the subcortical white matter with "severe atheromatosis of the arteries," enlarged ventricles and normal cortex.
1902 Use of the term "Binswanger's disease" by Alzheimer to identify this form of senile dementia.
1962: The term "subcortical arteriosclerotic encephalopathy" was first used
1974: The term "multi-infarct dementia" began to be used Multi-infarct dementia is a broader term for vascular dementia and includes both Binswanger's dementia and the dementia resulting from repeated thrombotic and embolic cerebral infarcts.
1987: The term "senile dementia of the Binswanger's type" was recommended

Affective disorders,alterations in mood and behavior are predominant features of senile dementia of the Binswanger's type. These mental status changes are typically found early in the course of the disease and may not accompany the neurologic findings. The changes vary in onset and severity but are present in most cases.